• DRAMP ID

    • DRAMP01202
    • Peptide Name

    • Fallaxidin 3.2 (Frogs, amphibians, animals)
    • Source

    • Litoria fallax (Eastern dwarf tree frog)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • GLLDFAKHVIGIASKLG
    • Sequence Length

    • 17
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+
    • Target Organism

      • Gram-positive bacteria: Enterococcus faecalis (MIC=100 µM), Lactococcus lactis (MIC=500 µM).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Amidation
    • Nonterminal Modifications and Unusual Amino Acids

    • Free
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01202 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01202.
    • Formula

    • C81H135N21O21
    • Absent Amino Acids

    • CEMNPQRTWY
    • Common Amino Acids

    • GL
    • Mass

    • 1739.09
    • PI

    • 8.6
    • Basic Residues

    • 3
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 9
    • Net Charge

    • +2
    • Boman Index

    • 10.18
    • Hydrophobicity

    • 0.853
    • Aliphatic Index

    • 143.53
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 4

DRAMP01202

    • Function

    • Fallaxidin-3.2 shows antibacterial activity against the Gram-positive bacteria.
    • Tissue specificity

    • Expressed by the skin dorsal glands.
  • ·Literature 1
    • Title

    • The fallaxidin peptides from the skin secretion of the Eastern Dwarf Tree Frog Litoria fallax. Sequence determination by positive and negative ion electrospray mass spectrometry: antimicrobial activity and cDNA cloning of the fallaxidins.
    • Reference

    • Rapid Commun Mass Spectrom. 2008 Oct;22(20):3207-3216.
    • Author

    • Jackway RJ, Bowie JH, Bilusich D, Musgrave IF, Surinya-Johnson KH, Tyler MJ, Eichinger PC.