General Information

    • DRAMP ID

    • DRAMP01204

    • Peptide Name

    • Fallaxidin 4.1 (Frogs, amphibians, animals)

    • Source

    • Litoria fallax (Eastern dwarf tree frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLLSFLPKVIGVIGHLIHPPS

    • Sequence Length

    • 21

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Lactococcus lactis (MIC=12 µM), Micrococcus luteus (MIC=100 µM), Staphylococcus epidermidis (MIC=100 µM), Streptococcus uberis (MIC=50 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01204 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01204.

Physicochemical Information

    • Formula

    • C106H172N26O24

    • Absent Amino Acids

    • ACDEMNQRTWY

    • Common Amino Acids

    • L

    • Mass

    • 2194.69

    • PI

    • 8.76

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +3

    • Boman Index

    • 26.65

    • Hydrophobicity

    • 1.048

    • Aliphatic Index

    • 157.62

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP01204

DRAMP01204 chydropathy plot

Comments Information

    • Function

    • Fallaxidin-4.1 shows antibacterial activity against the Gram-positive bacteria. Inhibits the formation of NO by neuronal nitric oxide synthase (IC50=13.3 µM).

    • Tissue specificity

    • Expressed by the skin dorsal glands.

Literature Information

  • ·Literature 1

    • Title

    • The fallaxidin peptides from the skin secretion of the Eastern Dwarf Tree Frog Litoria fallax. Sequence determination by positive and negative ion electrospray mass spectrometry: antimicrobial activity and cDNA cloning of the fallaxidins.

    • Reference

    • Rapid Commun Mass Spectrom. 2008 Oct;22(20):3207-3216.

    • Author

    • Jackway RJ, Bowie JH, Bilusich D, Musgrave IF, Surinya-Johnson KH, Tyler MJ, Eichinger PC.