General Information

    • DRAMP ID

    • DRAMP01207

    • Peptide Name

    • Galensin (Frogs, amphibians, animals)

    • Source

    • Kassina senegalensis (Senegal running frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • CYSAAKYPGFQEFINRKYKSSRF

    • Sequence Length

    • 23

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacterium: Escherichia coli;
      • Gram-positive bacterium: Micrococcus luteus.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01207 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01207.

Physicochemical Information

    • Formula

    • C129H188N34O34S

    • Absent Amino Acids

    • DHLMTVW

    • Common Amino Acids

    • FKSY

    • Mass

    • 2791.18

    • PI

    • 9.75

    • Basic Residues

    • 5

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +4

    • Boman Index

    • -56.4

    • Hydrophobicity

    • -0.891

    • Aliphatic Index

    • 25.65

    • Half Life

      • Mammalian:1.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 4470

    • Absorbance 280nm

    • 203.18

    • Polar Residues

    • 9

DRAMP01207

DRAMP01207 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against the Gram-positive bacteria

    • Tissue specificity

    • Expressed by the skin dorsal glands.

Literature Information

  • ·Literature 1

    • Title

    • Galensin, a novel homodimeric antimicrobial peptide from the defensive skin secretion of Kassina senegalensis: isolation, structural characterisation and cloning of precursor cDNA.

    • Reference

    • Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases

    • Author

    • Reid C.N, Bjourson A.J, Shaw C.