• DRAMP ID

    • DRAMP01208
    • Peptide Name

    • Pleurain-A1 (Pleurain A1; Frogs, amphibians, animals)
    • Source

    • Rana pleuraden (Yunnan pond frog)
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • SIITMTKEAKLPQLWKQIACRLYNTC
    • Sequence Length

    • 26
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-, Antimicrobial
    • Target Organism

      • [Ref.17764786]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=60 µg/ml), Helicobacter pylori NCTC 11637 (MIC=30 µg/ml);
      • Gram-positive bacteria: Bacillus dysenteriae (MIC=120 µg/ml), Staphylococcus aureus ATCC 2592 (MIC=15 µg/ml);
      • Yeast: Candida albicans ATCC 2002 (MIC=30 µg/ml)..
    • Hemolytic activity

      • [Ref:17764786]Little hemolytic activity on red blood cells even with peptide concentration up to 200 μg/ml
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • DRAMP01208 helical wheel diagram
    • Formula

    • C136H226N36O37S3
    • Absent Amino Acids

    • DFGHV
    • Common Amino Acids

    • IKLT
    • Mass

    • 3499.81
    • PI

    • 9.46
    • Basic Residues

    • 4
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 9
    • Boman Index

    • -26.97
    • Hydrophobicity

    • -5.77
    • Aliphatic Index

    • 97.69
    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 7115
    • Absorbance 280nm

    • 284.6
    • Polar Residues

    • 8

DRAMP01208

DRAMP01208 chydropathy plot
    • Function

    • Has little hemolytic activity on red blood cells.
    • Tissue specificity

    • Expressed by the skin dorsal glands.
  • Literature 1
    • Reference

    • Peptides. 2007 Oct;28(10):2069-2074.
    • Author

    • Wang X, Song Y, Li J, Liu H, Xu X, Lai R, Zhang K.
    • Title

    • A new family of antimicrobial peptides from skin secretions of Rana pleuraden