• DRAMP ID

    • DRAMP01209
    • Peptide Name

    • Pleurain-A2 (Pleurain A2; Frogs, amphibians, animals)
    • Source

    • Rana pleuraden (Yunnan pond frog)
    • Family

    • N/A
    • Gene

    • N/A
    • Sequence

    • SIITMTKEAKLPQSWKQIACRLYNTC
    • Sequence Length

    • 26
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-, Antimicrobial
    • Target Organism

      • [Ref.17764786]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=60 µg/ml), Helicobacter pylori NCTC 11637 (MIC=30 µg/ml);
      • Gram-positive bacteria: Bacillus dysenteriae (MIC=60 µg/ml), Staphylococcus aureus ATCC 2592 (MIC=15 µg/ml);
      • Yeast: Candida albicans ATCC 2002 (MIC=30 µg/ml).
    • Hemolytic Activity

      • [Ref:17764786]Little hemolytic activity on red blood cells even with peptide concentration up to 200 μg/ml
    • Cytotoxicity

    • Binding Target

    • N/A
    • Linear/Cyclic/Branched

    • N-terminal modification

    • C-terminal modification

    • Other modifications

    • Stereochemistry

    • Structure

    • N/A
    • Structure Description

    • N/A
    • DRAMP01209 helical wheel diagram
    • Formula

    • C133H220N36O38S3
    • Absent Amino Acids

    • DFGHV
    • Common Amino Acids

    • IKT
    • Mass

    • 3473.72
    • PI

    • 9.46
    • Basic Residues

    • 4
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 8
    • Boman Index

    • -35.29
    • Hydrophobicity

    • -23.46
    • Aliphatic Index

    • 82.69
    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 7115
    • Absorbance 280nm

    • 284.6
    • Polar Residues

    • 9

DRAMP01209

DRAMP01209 chydropathy plot
    • Function

    • Has little hemolytic activity on red blood cells.
    • Tissue specificity

    • Expressed by the skin dorsal glands.
  • Literature 1
    • Reference

    • Peptides. 2007 Oct;28(10):2069-2074.
    • Author

    • Wang X, Song Y, Li J, Liu H, Xu X, Lai R, Zhang K.
    • Title

    • A new family of antimicrobial peptides from skin secretions of Rana pleuraden.