General Information

    • DRAMP ID

    • DRAMP01213

    • Peptide Name

    • Pleurain-A4 (Pleurain A4; Frogs, amphibians, animals)

    • Source

    • Rana pleuraden (Yunnan pond frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • SIITTTKEAKLPQLWKQIACRLYNTC

    • Sequence Length

    • 26

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

    • [Swiss_Prot Entry A8B5Q0]has activity against Gram-positive and -negative bacteria, and fungi

    • Hemolytic Activity

      • [Ref:17764786]Little hemolytic activity on red blood cells even with peptide concentration up to 200 μg/ml

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01213 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01213.

Physicochemical Information

    • Formula

    • C135H224N36O38S2

    • Absent Amino Acids

    • DFGHMV

    • Common Amino Acids

    • T

    • Mass

    • 3023.6

    • PI

    • 9.3

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +3

    • Boman Index

    • -31.89

    • Hydrophobicity

    • -0.158

    • Aliphatic Index

    • 97.69

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 7115

    • Absorbance 280nm

    • 284.6

    • Polar Residues

    • 9

DRAMP01213

DRAMP01213 chydropathy plot

Comments Information

    • Function

    • Has little hemolytic activity on red blood cells.

    • Tissue specificity

    • Expressed by the skin dorsal glands.

Literature Information

  • ·Literature 1

    • Title

    • A new family of antimicrobial peptides from skin secretions of Rana pleuraden.

    • Reference

    • Peptides. 2007 Oct;28(10):2069-2074.

    • Author

    • Wang X, Song Y, Li J, Liu H, Xu X, Lai R, Zhang K.