• DRAMP ID

    • DRAMP01215
    • Peptide Name

    • Kassinatuerin-2Mb (Frogs, amphibians, animals)
    • Source

    • Kassina maculata (African hyperoliid frog)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • FFGAIAAALPHVISAIKNAL
    • Sequence Length

    • 20
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+
    • Target Organism

      • [Ref.19427345]Gram-positive bacterium: Staphylococcus aureus
    • Hemolytic Activity

      • [Ref:19427345]18% hemolytic activity at 16 μM, 45–50% hemolytic activity at 120 μM against horse erythrocytes
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Alpha helix
    • Structure Description

    • Secondary structure prediction analysis revealed that virtually the entire structure of each kassinatuerin-2 related peptide is composed of alpha-helix, the helix was not amphipathic like many other amphibian skin antimicrobial peptides, in which there is a hydrophobic face and a positively charged faces the latter presumably interacting with the negatively charged glycocalyx of cell membranes.
    • Helical Wheel Diagram

    • DRAMP01215 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01215.
    • Formula

    • C97H154N24O23
    • Absent Amino Acids

    • CDEMQRTWY
    • Common Amino Acids

    • A
    • Mass

    • 2024.44
    • PI

    • 8.76
    • Basic Residues

    • 2
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 14
    • Net Charge

    • +2
    • Boman Index

    • 26.15
    • Hydrophobicity

    • 1.415
    • Aliphatic Index

    • 142
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 3

DRAMP01215

DRAMP01215 chydropathy plot
    • Function

    • Has relatively potent growth inhibitory activity against the Gram-positive bacterium, S. aureus, but were ineffective against the Gram-negative bacterium, E. coli and were relatively ineffective against the pathogenic yeast, C. albicans. Has hemolytic activity as demonstrated using horse erythrocytes.
  • ·Literature 1
    • Title

    • A family of kassinatuerin-2 related peptides from the skin secretion of the African hyperoliid frog, Kassina maculata.
    • Reference

    • Peptides. 2009 Aug;30(8):1428-1433.
    • Author

    • Wang L, Zhou M, McGrath S, Chen T, Gorman SP, Walker B, Shaw C.