• DRAMP ID

    • DRAMP01218
    • Peptide Name

    • Kassinatuerin-1 (Frogs, amphibians, animals)
    • Source

    • Kassina senegalensis (Senegal running frog)
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • GFMKYIGPLIPHAVKAISDLI
    • Sequence Length

    • 21
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-, Antimicrobial
    • Target Organism

      • Gram-negative bacteria: Escherichia coli (MIC=6.25 µM), Klebsiella pneumoniae (MIC=25 µM), Enterobacter cloacae (MIC=6.25 µM), Pseudomonas aeruginosa (MIC=25 µM);
      • Gram-positive bacteria: Staphylococcus aureus (MIC=6.25 µM), Staphylococcus epidermidis (MIC=6.25 µM), Enterococcus faecalis (MIC=12.5 µM).
      • Yeast: Candida albicans (MIC=100 µM).
    • Hemolytic activity

    • Unknown
    • Binding Target

    • Unknown
    • Structure

    • Alpha helix
    • Structure Description

    • Unknown
    • DRAMP01218 helical wheel diagram
    • Formula

    • C109H175N25O26S
    • Absent Amino Acids

    • CENQRTW
    • Common Amino Acids

    • I
    • Mass

    • 2640.74
    • PI

    • 9.26
    • Basic Residues

    • 3
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 10
    • Boman Index

    • 16.37
    • Hydrophobicity

    • 83.33
    • Aliphatic Index

    • 134.76
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 1490
    • Absorbance 280nm

    • 74.5
    • Polar Residues

    • 4

DRAMP01218

DRAMP01218 chydropathy plot
    • Function

    • Shows broad-spectrum antimicrobial activity.
    • Tissue specificity

    • Expressed by the skin dorsal glands.
  • Literature 1
    • Reference

    • Biochem Biophys Res Commun. 2000 Feb 16;268(2):433-436.
    • Author

    • Mattute B, Knoop FC, Conlon JM.
    • Title

    • Kassinatuerin-1: a peptide with broad-spectrum antimicrobial activity isolated from the skin of the hyperoliid frog, Kassina senegalensis.
  • Literature 2
    • Reference

    • Peptides. 2005 Nov;26(11):2104-2110.
    • Author

    • Conlon JM, Abraham B, Galadari S, Knoop FC, Sonnevend A, P¡l T.
    • Title

    • Antimicrobial and cytolytic properties of the frog skin peptide, kassinatuerin-1 and its L- and D-lysine-substituted derivatives.