• DRAMP ID

    • DRAMP01234
    • Peptide Name

    • Palustrin-3a (Frogs, amphibians, animals)
    • Source

    • Rana palustris (Pickerel frog)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • GIFPKIIGKGIKTGIVNGIKSLVKGVGMKVFKAGLNNIGNTGCNEDEC
    • Sequence Length

    • 48
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-
    • Target Organism

      • Gram-negative bacterium: Escherichia coli (MIC=1 µM).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Cyclization (Cys43 and Cys48)
    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys43 and Cys48.
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01234 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01234.
    • Formula

    • C218H368N60O63S3
    • Absent Amino Acids

    • HQRWY
    • Common Amino Acids

    • G
    • Mass

    • 4933.86
    • PI

    • 9.45
    • Basic Residues

    • 7
    • Acidic Residues

    • 3
    • Hydrophobic Residues

    • 16
    • Net Charge

    • +4
    • Boman Index

    • -20.41
    • Hydrophobicity

    • 0.148
    • Aliphatic Index

    • 99.38
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 2.66
    • Polar Residues

    • 20

DRAMP01234

DRAMP01234 chydropathy plot
    • Tissue specificity

    • Expressed by the skin glands.
  • ·Literature 1
    • Title

    • Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris.
    • Reference

    • Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105.
    • Author

    • Basir YJ, Knoop FC, Dulka J, Conlon JM.