• DRAMP ID

    • DRAMP01244
    • Peptide Name

    • Japonicin-1 (Frogs, amphibians, animals)
    • Source

    • Rana japonica (Japanese brown frog)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • Unknown
    • Sequence

    • FFPIGVFCKIFKTC
    • Sequence Length

    • 14
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Anti-Gram+, Anti-Gram-, Antimicrobial
    • Target Organism

      • Gram-negative bacterium: Escherichia coli (MIC=30 µM);
      • Gram-positive bacterium: Staphylococcus aureus (MIC>100 µM).
    • Hemolytic activity

    • Unknown
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • DRAMP01244 helical wheel diagram
    • Formula

    • C82H120N16O16S2
    • Absent Amino Acids

    • ADEHLMNQRSWY
    • Common Amino Acids

    • F
    • Mass

    • 1882.13
    • PI

    • 8.82
    • Basic Residues

    • 2
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 7
    • Boman Index

    • 15.63
    • Hydrophobicity

    • 135
    • Aliphatic Index

    • 76.43
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 9.62
    • Polar Residues

    • 4

DRAMP01244

    • Tissue specificity

    • Expressed by the skin dorsal glands.
  • Literature 1
    • Reference

    • Peptides. 2002;23:419-425
    • Author

    • Isaacson T, Soto A, Iwamuro S, Knoop FC, Conlon JM.
    • Title

    • Antimicrobial peptides with atypical structural features from the skin of the Japanese brown frog Rana japonica.