• DRAMP ID

    • DRAMP01245
    • Peptide Name

    • Japonicin-1CDYa (Frogs, amphibians, animals)
    • Source

    • Rana dybowskii (Dybovsky's frog) (Korean brown frog)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • N/A
    • Sequence

    • FFPLALLCKVFKKC
    • Sequence Length

    • 14
    • Evidence code

    • Transcript level
    • Biological Activity

    • Antibacterial, Anti-Gram+, Anti-Gram-, Antimicrobial
    • Target Organism

      • [Ref.19539775]Gram-positive bacterium: Staphylococcus aureus (MIC>100 µM);
      • Gram-negative bacterium: Escherichia coli (MIC=25 µM).
    • Hemolytic Activity

      • [Ref:19539775]HC50>300 μM against human red blood cells
    • Cytotoxicity

    • Binding Target

    • N/A
    • Linear/Cyclic/Branched

    • N-terminal modification

    • C-terminal modification

    • Other modifications

    • Stereochemistry

    • Structure

    • N/A
    • Structure Description

    • N/A
    • DRAMP01245 helical wheel diagram
    • Formula

    • C82H129N17O15S2
    • Absent Amino Acids

    • DEGHIMNQRSTWY
    • Common Amino Acids

    • FKL
    • Mass

    • 1889.22
    • PI

    • 9.67
    • Basic Residues

    • 3
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 8
    • Boman Index

    • 15.46
    • Hydrophobicity

    • 125
    • Aliphatic Index

    • 111.43
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 9.62
    • Polar Residues

    • 2

DRAMP01245

    • Function

    • Antimicrobial peptide. Lacks hemolytic activity against human erythrocytes.
    • Tissue specificity

    • Expressed by the skin glands.
  • Literature 1
    • Reference

    • Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):174-178.
    • Author

    • Jin LL, Li Q, Song SS, Feng K, Zhang DB, Wang QY, Chen YH.
    • Title

    • Characterization of antimicrobial peptides isolated from the skin of the Chinese frog, Rana dybowskii.