• DRAMP ID

    • DRAMP01246
    • Peptide Name

    • Japonicin-2 (Frogs, amphibians, animals)
    • Source

    • Rana japonica (Japanese brown frog)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • N/A
    • Sequence

    • FGLPMLSILPKALCILLKRKC
    • Sequence Length

    • 21
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Anti-Gram+, Anti-Gram-, Antimicrobial
    • Target Organism

      • Gram-negative bacterium: Escherichia coli (MIC=12 µM);
      • Gram-positive bacterium: Staphylococcus aureus (MIC=20 µM).
    • Hemolytic Activity

      • N/A
    • Cytotoxicity

    • Binding Target

    • N/A
    • Linear/Cyclic/Branched

    • N-terminal modification

    • C-terminal modification

    • Other modifications

    • Stereochemistry

    • Structure

    • N/A
    • Structure Description

    • N/A
    • DRAMP01246 helical wheel diagram
    • Formula

    • C110H193N27O23S3
    • Absent Amino Acids

    • DEHNQTVWY
    • Common Amino Acids

    • L
    • Mass

    • 2715.03
    • PI

    • 10.51
    • Basic Residues

    • 4
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 10
    • Boman Index

    • 15.03
    • Hydrophobicity

    • 108.1
    • Aliphatic Index

    • 153.33
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 6.25
    • Polar Residues

    • 4

DRAMP01246

DRAMP01246 chydropathy plot
    • Tissue specificity

    • Expressed by the skin glands.
  • Literature 1
    • Reference

    • Peptides. 2002;23:419-425.
    • Author

    • Isaacson T, Soto A, Iwamuro S, Knoop FC, Conlon JM.
    • Title

    • Antimicrobial peptides with atypical structural features from the skin of the Japanese brown frog Rana japonica.