• DRAMP ID

    • DRAMP01249
    • Peptide Name

    • Dybowskin-2 (Frogs, amphibians, animals)
    • Source

    • Rana dybowskii (Korea brown frog)
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • FLIGMTQGLICLITRKC
    • Sequence Length

    • 17
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Unknown
    • Biological Activity

    • Antibacterial, Anti-Gram+, Anti-Gram-, Antimicrobial
    • Target Organism

      • [Ref.17698251]Gram-positive bacteria: Micrococcus luteus ATCC4698 (MIC=6.25 µg/ml), Staphylococcus aureus KCTC3881 (MIC=15 µg/ml), Bacillus subtilis ATCC6633 (MIC=25 µg/ml), Staphylococcus epidermidis ATCC12228 (MIC=25 µg/ml);
      • Gram-negative bacteria: Shigella dysenteriae ATCC9752 (MIC=50 µg/ml), Escherichia coli KCTC2433 (MIC=60 µg/ml), Klebsiella pneumoniae ATCC10031 (MIC=60 µg/ml), Proteus mirabilis ATCC25933 (MIC>100 µg/ml);
      • Yeast: Candida albicans ATCC36232 (MIC=100 µg/ml).
    • Hemolytic activity

      • [Ref:17698251]10.99% hemolytic activity at 100 μg/ml against human red blood cells
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • DRAMP01249 helical wheel diagram
    • Formula

    • C85H148N22O21S3
    • Absent Amino Acids

    • ADEHNPSVWY
    • Common Amino Acids

    • IL
    • Mass

    • 2196.02
    • PI

    • 8.83
    • Basic Residues

    • 2
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 7
    • Boman Index

    • 8.14
    • Hydrophobicity

    • 120.59
    • Aliphatic Index

    • 137.65
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 7.81
    • Polar Residues

    • 6

DRAMP01249

    • Function

    • Dybowskin-2 has hemolytic activity against human red blood cells (hRBCs).
  • Literature 1
    • Reference

    • Peptides 2007; 28: 1532-1539.
    • Author

    • Kim SS, Shim MS, Chung J, Lim DY, Lee BJ.
    • Title

    • Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii.