• DRAMP ID

    • DRAMP01251
    • Peptide Name

    • Dybowskin-4 (Frogs, amphibians, animals)
    • Source

    • Rana dybowskii (Korea brown frog)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • VWPLGLVICKALKIC
    • Sequence Length

    • 15
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
    • Target Organism

      • [Ref.17698251]Gram-positive bacteria: Micrococcus luteus ATCC4698 (MIC=1.56 µg/ml), Staphylococcus aureus KCTC3881 (MIC=3.13 µg/ml), Bacillus subtilis ATCC6633 (MIC=6.25 µg/ml), Staphylococcus epidermidis ATCC12228 (MIC=6.25 µg/ml);
      • Gram-negative bacteria: Shigella dysenteriae ATCC9752 (MIC=30 µg/ml), Escherichia coli KCTC2433 (MIC=15 µg/ml), Klebsiella pneumoniae ATCC10031 (MIC=15 µg/ml);
      • Yeast: Candida albicans ATCC36232 (MIC=25 µg/ml).
    • Hemolytic Activity

      • [Ref:17698251] It has 47.58% hemolytic activity at 100 μg/ml against human red blood cells
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Cyclization (Cys9 and Cys15)
    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys9 and Cys15.
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01251 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01251.
    • Formula

    • C79H134N18O16S2
    • Absent Amino Acids

    • DEFHMNQRSTY
    • Common Amino Acids

    • L
    • Mass

    • 1656.16
    • PI

    • 8.9
    • Basic Residues

    • 2
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 9
    • Net Charge

    • +2
    • Boman Index

    • 29.22
    • Hydrophobicity

    • 1.66
    • Aliphatic Index

    • 175.33
    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5625
    • Absorbance 280nm

    • 401.79
    • Polar Residues

    • 3

DRAMP01251

    • Function

    • Dybowskin-4 has relatively greater hemolytic activity against human red blood cells (hRBCs).
  • ·Literature 1
    • Title

    • Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii.
    • Reference

    • Peptides 2007; 28: 1532-1539.
    • Author

    • Kim SS, Shim MS, Chung J, Lim DY, Lee BJ.