General Information
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DRAMP ID
- DRAMP01252
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Peptide Name
- Dybowskin-5 (Frogs, amphibians, animals)
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Source
- Rana dybowskii (Korea brown frog)
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Family
- Not found
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Gene
- Not found
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Sequence
- GLFSVVTGVLKAVGKNVAKNVGGSLLEQLKCKKISGGC
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Sequence Length
- 38
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Swiss_Prot Entry
- No entry found
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Evidence code
- Not found
Activity Information
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Biological Activity
- Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-, Antimicrobial
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Target Organism
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- [Ref.17698251]Gram-positive bacteria: Micrococcus luteus ATCC4698 (MIC=6.25 µg/ml), Staphylococcus aureus KCTC3881 (MIC=25 µg/ml), Bacillus subtilis ATCC6633 (MIC=50 µg/ml), Staphylococcus epidermidis ATCC12228 (MIC=50 µg/ml);
- Gram-negative bacteria: Shigella dysenteriae ATCC9752 (MIC=50 µg/ml), Escherichia coli KCTC2433 (MIC=60 µg/ml), Klebsiella pneumoniae ATCC10031 (MIC=50 µg/ml);
- Yeast: Candida albicans ATCC36232 (MIC=50 µg/ml).
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Hemolytic Activity
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- [Ref:17698251]17.84% hemolytic activity at 100 μg/ml against human red blood cells
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
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Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Other Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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PDB ID
- None
-
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Physicochemical Information
-
Formula
- C168H293N47O48S2
Absent Amino Acids
- DHMPRWY
Common Amino Acids
- G
Mass
- 4463.75
PI
- 10.51
Basic Residues
- 6
Acidic Residues
- 1
Hydrophobic Residues
- 15
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Boman Index
- -2.2
Hydrophobicity
- 0.442
Aliphatic Index
- 112.63
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 3.38
Polar Residues
- 15
DRAMP01252

Comments Information
Function
- Dybowskin-5 has hemolytic activity against human red blood cells (hRBCs).
Literature Information
- ·Literature 1
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Title
- Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii.
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Pubmed ID
- 17698251
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Reference
- Peptides 2007; 28: 1532-1539.
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Author
- Kim SS, Shim MS, Chung J, Lim DY, Lee BJ.