• DRAMP ID

    • DRAMP01252
    • Peptide Name

    • Dybowskin-5 (Frogs, amphibians, animals)
    • Source

    • Rana dybowskii (Korea brown frog)
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • GLFSVVTGVLKAVGKNVAKNVGGSLLEQLKCKKISGGC
    • Sequence Length

    • 38
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Unknown
    • Biological Activity

    • Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-, Antimicrobial
    • Target Organism

      • [Ref.17698251]Gram-positive bacteria: Micrococcus luteus ATCC4698 (MIC=6.25 µg/ml), Staphylococcus aureus KCTC3881 (MIC=25 µg/ml), Bacillus subtilis ATCC6633 (MIC=50 µg/ml), Staphylococcus epidermidis ATCC12228 (MIC=50 µg/ml);
      • Gram-negative bacteria: Shigella dysenteriae ATCC9752 (MIC=50 µg/ml), Escherichia coli KCTC2433 (MIC=60 µg/ml), Klebsiella pneumoniae ATCC10031 (MIC=50 µg/ml);
      • Yeast: Candida albicans ATCC36232 (MIC=50 µg/ml).
    • Hemolytic activity

      • [Ref:17698251]17.84% hemolytic activity at 100 μg/ml against human red blood cells
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • DRAMP01252 helical wheel diagram
    • Formula

    • C168H293N47O48S2
    • Absent Amino Acids

    • DHMPRWY
    • Common Amino Acids

    • G
    • Mass

    • 4463.75
    • PI

    • 10.51
    • Basic Residues

    • 6
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 15
    • Boman Index

    • -2.2
    • Hydrophobicity

    • 44.21
    • Aliphatic Index

    • 112.63
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 3.38
    • Polar Residues

    • 15

DRAMP01252

DRAMP01252 chydropathy plot
    • Function

    • Dybowskin-5 has hemolytic activity against human red blood cells (hRBCs).
  • Literature 1
    • Reference

    • Peptides 2007; 28: 1532-1539.
    • Author

    • Kim SS, Shim MS, Chung J, Lim DY, Lee BJ.
    • Title

    • Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii.