• DRAMP ID

    • DRAMP01253
    • Peptide Name

    • Dybowskin-6 (Frogs, amphibians, animals)
    • Source

    • Rana dybowskii (Korea brown frog)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • FLPLLLAGLPLKLCFLFKKC
    • Sequence Length

    • 20
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Antifungal
    • Target Organism

      • Gram-positive bacteria: Micrococcus luteus ATCC4698 (MIC=6.25 µg/ml), Staphylococcus aureus KCTC3881 (MIC=12.5 µg/ml), Bacillus subtilis ATCC6633 (MIC=50 µg/ml), Staphylococcus epidermidis ATCC12228 (MIC=50 µg/ml).
      • Yeast: Candida albicans (MIC=50 µg/ml).
    • Hemolytic Activity

      • [Ref:17698251] It has 59.39% hemolytic activity at 100 μg/ml against huamn red blood cells
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • [Ref:17698251]59.39% hemolytic activity at 100 μg/ml against huamn red blood cells
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Cyclization (Cys14 and Cys20)
    • Other Modifications and Unusual Amino Acids

    • Disulfide bond between Cys14 and Cys20.
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • PDB ID

    • None
    • DRAMP01253 helical wheel diagram
    • Formula

    • C114H185N23O21S2
    • Absent Amino Acids

    • DEHIMNQRSTVWY
    • Common Amino Acids

    • L
    • Mass

    • 2277.98
    • PI

    • 9.39
    • Basic Residues

    • 3
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 12
    • Net Charge

    • +3
    • Boman Index

    • 36.96
    • Hydrophobicity

    • 1.515
    • Aliphatic Index

    • 161
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 6.58
    • Polar Residues

    • 3

DRAMP01253

DRAMP01253 chydropathy plot
    • Function

    • Dybowskin-6 has relatively greater hemolytic activity against human red blood cells (hRBCs).
  • ·Literature 1
    • Title

    • Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii.
    • Reference

    • Peptides. 2007 Aug;28(8):1532-1539.
    • Author

    • Kim SS, Shim MS, Chung J, Lim DY, Lee BJ.