• DRAMP ID

    • DRAMP01255
    • Peptide Name

    • Dybowskin-2CDYa (Chensinin-1; Frogs, amphibians, animals)
    • Source

    • Rana dybowskii (Dybovsky's frog) (Korean brown frog)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • SAVGRHGRRFGLRKHRKH
    • Sequence Length

    • 18
    • Protein Existence

    • Transcript level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.19539775] Gram-negative bacterium: Escherichia coli (MIC=3 µM);
      • Gram-negative bacterium: Staphylococcus aureus (MIC=6 µM).
      • [Ref.19341344] Gram-positive bacteria: Staphylococcus aureus (MIC=14.4 µM), Bacillus cereus (MIC=14.4 µM), Streptococcus lactis (MIC=14.4 µM).
    • Hemolytic Activity

      • [Ref:19539775]HC50>300 μM against human red blood cells
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Other Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • PDB ID

    • None
    • DRAMP01255 helical wheel diagram
    • Formula

    • C92H155N41O20
    • Absent Amino Acids

    • CDEIMNPQTWY
    • Common Amino Acids

    • R
    • Mass

    • 2155.51
    • PI

    • 12.6
    • Basic Residues

    • 10
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 4
    • Net Charge

    • +10
    • Boman Index

    • -86.51
    • Hydrophobicity

    • -1.628
    • Aliphatic Index

    • 43.33
    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 4

DRAMP01255

DRAMP01255 chydropathy plot
    • Function

    • Antimicrobial peptide. Has activity against the Gram-positive bacteria
    • Tissue specificity

    • Expressed by the skin glands.
  • ·Literature 1
    • Title

    • Characterization of antimicrobial peptides isolated from the skin of the Chinese frog, Rana dybowskii.
    • Reference

    • Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):174-178.
    • Author

    • Jin LL, Li Q, Song SS, Feng K, Zhang DB, Wang QY, Chen YH.
  • ·Literature 2
    • Title

    • Molecular cloning of cDNAs encoding antimicrobial peptide precursors from the skin of the Chinese brown frog, Rana chensinensis.
    • Reference

    • Zoolog Sci. 2009 Mar;26(3):220-226.
    • Author

    • Shang D, Yu F, Li J, Zheng J, Zhang L, Li Y.