• DRAMP ID

    • DRAMP01255
    • Peptide Name

    • Dybowskin-2CDYa (Chensinin-1; Frogs, amphibians, animals)
    • Source

    • Rana dybowskii (Dybovsky's frog) (Korean brown frog)
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • SAVGRHGRRFGLRKHRKH
    • Sequence Length

    • 18
    • Evidence code

    • Transcript level
    • Biological Activity

    • Antibacterial, Anti-Gram+, Anti-Gram-, Antimicrobial
    • Target Organism

      • [Ref.19539775] Gram-negative bacterium: Escherichia coli (MIC=3 µM);
      • Gram-negative bacterium: Staphylococcus aureus (MIC=6 µM).
      • [Ref.19341344] Gram-positive bacteria: Staphylococcus aureus (MIC=14.4 µM), Bacillus cereus (MIC=14.4 µM), Streptococcus lactis (MIC=14.4 µM).
    • Hemolytic activity

      • [Ref:19539775]HC50>300 μM against human red blood cells
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • DRAMP01255 helical wheel diagram
    • Formula

    • C92H155N41O20
    • Absent Amino Acids

    • CDEIMNPQTWY
    • Common Amino Acids

    • R
    • Mass

    • 2458.9
    • PI

    • 13.11
    • Basic Residues

    • 10
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 4
    • Boman Index

    • -86.51
    • Hydrophobicity

    • -162.78
    • Aliphatic Index

    • 43.33
    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 4

DRAMP01255

DRAMP01255 chydropathy plot
    • Function

    • Antimicrobial peptide. Has activity against the Gram-positive bacteria
    • Tissue specificity

    • Expressed by the skin glands.
  • Literature 1
    • Reference

    • Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):174-178.
    • Author

    • Jin LL, Li Q, Song SS, Feng K, Zhang DB, Wang QY, Chen YH.
    • Title

    • Characterization of antimicrobial peptides isolated from the skin of the Chinese frog, Rana dybowskii.
  • Literature 2
    • Reference

    • Zoolog Sci. 2009 Mar;26(3):220-226.
    • Author

    • Shang D, Yu F, Li J, Zheng J, Zhang L, Li Y.
    • Title

    • Molecular cloning of cDNAs encoding antimicrobial peptide precursors from the skin of the Chinese brown frog, Rana chensinensis.