General Information
-
DRAMP ID
- DRAMP01257
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Peptide Name
- Dermadistinctin-K (DD K; Frogs, amphibians, animals)
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Source
- Phyllomedusa distincta (Monkey frog)
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Family
- Not found
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Gene
- Not found
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Sequence
- GLWSKIKAAGKEAAKAAAKAAGKAALNAVSEAV
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Sequence Length
- 33
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Swiss_Prot Entry
- P83638
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Evidence code
- Protein level
Activity Information
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Biological Activity
- Antibacterial, Antifungal, Antiprotozoal, Anti-Gram+, Anti-Gram-, Antimicrobial
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Target Organism
-
- Gram-positive bacteria: Staphylococcus aureus (MIC=4.7 µM), Enterococcus faecalis (MIC>19 µM);Gram-negative bacteria: Pseudomonas aeruginosa (MIC=2.4 µM), Escherichia coli (MIC=0.6 µM).
- Fungi: Candida tropicalis (MIC=10.1 µM), Candida guilliermondii (MIC=20.3 µM), Candida albicans (MIC=20.3 µM), Candida albicans ATCC 1023 (MIC=10.1 µM).
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Hemolytic Activity
-
- Not found
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Cytotoxicity
-
- Not included yet
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Binding Target
- liposomes
Structure Information
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Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Other Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Alpha helix
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Structure Description
- Not found
-
-
-
2K9B-> 
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Physicochemical Information
-
Formula
- C140H239N41O41
Absent Amino Acids
- CDFHMPQRTY
Common Amino Acids
- A
Mass
- 3723.7
PI
- 10.8
Basic Residues
- 6
Acidic Residues
- 2
Hydrophobic Residues
- 19
-
Boman Index
- -8.84
Hydrophobicity
- 0.191
Aliphatic Index
- 92.42
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 171.88
Polar Residues
- 6
DRAMP01257

Comments Information
Function
- Also has antiprotozoal activity against Trypanosoma cruzi. Decreases viability of murine peritoneal cells. Fuses to, and disrupts liposomes.
Tissue specificity
- Expressed by the skin glands.
Literature Information
- ·Literature 1
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Title
- Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta.
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Pubmed ID
- 10477123
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Reference
- Peptides. 1999;20(6):679-686.
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Author
- Batista CV, da Silva LR, Sebben A, Scaloni A, Ferrara L, Paiva GR, Olamendi-Portugal T, Possani LD, Bloch C Jr.