• DRAMP ID

    • DRAMP01257
    • Peptide Name

    • Dermadistinctin-K (DD K; Frogs, amphibians, animals)
    • Source

    • Phyllomedusa distincta (Monkey frog)
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • GLWSKIKAAGKEAAKAAAKAAGKAALNAVSEAV
    • Sequence Length

    • 33
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Antifungal, Antiprotozoal, Anti-Gram+, Anti-Gram-, Antimicrobial
    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus (MIC=4.7 µM), Enterococcus faecalis (MIC>19 µM);Gram-negative bacteria: Pseudomonas aeruginosa (MIC=2.4 µM), Escherichia coli (MIC=0.6 µM).
      • Fungi: Candida tropicalis (MIC=10.1 µM), Candida guilliermondii (MIC=20.3 µM), Candida albicans (MIC=20.3 µM), Candida albicans ATCC 1023 (MIC=10.1 µM).
    • Hemolytic activity

    • Unknown
    • Binding Target

    • liposomes
    • Structure

    • Alpha helix
    • Structure Description

    • Unknown
    • DRAMP01257 helical wheel diagram
    • 2K9B-> 
    • Formula

    • C140H239N41O41
    • Absent Amino Acids

    • CDFHMPQRTY
    • Common Amino Acids

    • A
    • Mass

    • 3723.7
    • PI

    • 10.8
    • Basic Residues

    • 6
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 19
    • Boman Index

    • -8.84
    • Hydrophobicity

    • 19.09
    • Aliphatic Index

    • 92.42
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5500
    • Absorbance 280nm

    • 171.88
    • Polar Residues

    • 6

DRAMP01257

DRAMP01257 chydropathy plot
    • Function

    • Also has antiprotozoal activity against Trypanosoma cruzi. Decreases viability of murine peritoneal cells. Fuses to, and disrupts liposomes.
    • Tissue specificity

    • Expressed by the skin glands.
  • Literature 1
    • Reference

    • Peptides. 1999;20(6):679-686.
    • Author

    • Batista CV, da Silva LR, Sebben A, Scaloni A, Ferrara L, Paiva GR, Olamendi-Portugal T, Possani LD, Bloch C Jr.
    • Title

    • Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta.