General Information

    • DRAMP ID

    • DRAMP01265

    • Peptide Name

    • Des-Arg-[Thr6]-bradykinin (Frogs, amphibians, animals)

    • Source

    • Phasmahyla jandaia (Jandaia leaf frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RPPGFTPF

    • Sequence Length

    • 8

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01265 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01265.

Physicochemical Information

    • Formula

    • C45H63N11O10

    • Absent Amino Acids

    • ACDEHIKLMNQSVWY

    • Common Amino Acids

    • P

    • Mass

    • 918.06

    • PI

    • 9.75

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 2

    • Net Charge

    • +1

    • Boman Index

    • -10.59

    • Hydrophobicity

    • -0.6

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP01265

Comments Information

    • Function

    • Produces in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle. Amphibian defense peptide.

    • Tissue specificity

    • Expressed by the skin glands.

Literature Information

  • ·Literature 1

    • Title

    • Peptidomic dissection of the skin secretion of Phasmahyla jandaia (Bokermann and Sazima, 1978) (Anura, Hylidae, Phyllomedusinae).

    • Reference

    • Toxicon. 2011 Jan;57(1):35-52.

    • Author

    • Rates B, Silva LP, Ireno IC, Leite FS, Borges MH, Bloch C Jr, De Lima ME, Pimenta AM.