• DRAMP ID

    • DRAMP01267
    • Peptide Name

    • [Thr6]-Phyllokinin (Frogs, amphibians, animals)
    • Source

    • Phasmahyla jandaia (Jandaia leaf frog)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • RPPGFTPFRIY
    • Sequence Length

    • 11
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial
    • Target Organism

    • No MICs found in DRAMP database
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01267 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01267.
    • Formula

    • C66H95N17O14
    • Absent Amino Acids

    • ACDEHKLMNQSVW
    • Common Amino Acids

    • P
    • Mass

    • 1350.59
    • PI

    • 10.84
    • Basic Residues

    • 2
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 3
    • Net Charge

    • +2
    • Boman Index

    • -20.73
    • Hydrophobicity

    • -0.555
    • Aliphatic Index

    • 35.45
    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 1490
    • Absorbance 280nm

    • 149
    • Polar Residues

    • 3

DRAMP01267

    • Function

    • Produces in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle, Amphibian defense peptide.
    • Tissue specificity

    • Expressed by the skin glands.
    • Note

    • Sequence uncertainty at position 10 (I or L).
  • ·Literature 1
    • Title

    • Peptidomic dissection of the skin secretion of Phasmahyla jandaia (Bokermann and Sazima, 1978) (Anura, Hylidae, Phyllomedusinae).
    • Reference

    • Toxicon. 2011 Jan;57(1):35-52.
    • Author

    • Rates B, Silva LP, Ireno IC, Leite FS, Borges MH, Bloch C Jr, De Lima ME, Pimenta AM.