General Information
-
DRAMP ID
- DRAMP01267
-
Peptide Name
- [Thr6]-Phyllokinin (Frogs, amphibians, animals)
-
Source
- Phasmahyla jandaia (Jandaia leaf frog)
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- RPPGFTPFRIY
-
Sequence Length
- 11
-
UniProt Entry
- P86632
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial
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Target Organism
- No MICs found in DRAMP database
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01267.
Physicochemical Information
-
Formula
- C66H95N17O14
Absent Amino Acids
- ACDEHKLMNQSVW
Common Amino Acids
- P
Mass
- 1350.59
PI
- 10.84
Basic Residues
- 2
Acidic Residues
- 0
Hydrophobic Residues
- 3
Net Charge
- +2
-
Boman Index
- -20.73
Hydrophobicity
- -0.555
Aliphatic Index
- 35.45
Half Life
-
- Mammalian:1 hour
- Yeast:2 min
- E.coli:2 min
Extinction Coefficient Cystines
- 1490
Absorbance 280nm
- 149
Polar Residues
- 3
DRAMP01267
Comments Information
Function
- Produces in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle, Amphibian defense peptide.
Tissue specificity
- Expressed by the skin glands.
Note
- Sequence uncertainty at position 10 (I or L).
Literature Information
- ·Literature 1
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Title
- Peptidomic dissection of the skin secretion of Phasmahyla jandaia (Bokermann and Sazima, 1978) (Anura, Hylidae, Phyllomedusinae).
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Pubmed ID
- 20932854
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Reference
- Toxicon. 2011 Jan;57(1):35-52.
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Author
- Rates B, Silva LP, Ireno IC, Leite FS, Borges MH, Bloch C Jr, De Lima ME, Pimenta AM.