General Information
-
DRAMP ID
- DRAMP01288
-
Peptide Name
- Phylloseptin-1 (PSN-1; Frogs, amphibians, animals)
-
Source
- Phyllomedusa sauvagei (Sauvage's leaf frog)
-
Family
- Not found
-
Gene
- PSN-1
-
Sequence
- FLSLIPHIVSGVASIAKHF
-
Sequence Length
- 19
-
UniProt Entry
- E3PQH3
-
Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Antifungal
-
Target Organism
- S. aureus (MIC=5 µM), Escherichia coli and Candida albicans.
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- Free
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01288.
Physicochemical Information
-
Formula
- C98H154N24O23
Absent Amino Acids
- CDEMNQRTWY
Common Amino Acids
- IS
Mass
- 2036.45
PI
- 8.76
Basic Residues
- 3
Acidic Residues
- 0
Hydrophobic Residues
- 11
Net Charge
- +3
-
Boman Index
- 18.13
Hydrophobicity
- 1.263
Aliphatic Index
- 143.68
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 4
DRAMP01288
Comments Information
Function
- PSN-1 displayed broad-spectrum activity against a range of planktonic organisms.
Literature Information
- ·Literature 1
-
Title
- Phylloseptin-1 (PSN-1) from Phyllomedusa sauvagei skin secretion: a novel broad-spectrum antimicrobial peptide with antibiofilm activity.
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Pubmed ID
- 20451254
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Reference
- Mol Immunol. 2010 Jul;47(11-12):2030-2037.
-
Author
- Zhang R, Zhou M, Wang L, McGrath S, Chen T, Chen X, Shaw C.