General Information

    • DRAMP ID

    • DRAMP01292

    • Peptide Name

    • Phylloseptin-4 (PS-4; Frogs, amphibians, animals)

    • Source

    • Phyllomedusa oreades (Orange-legged leaf frog) (Monkey frog)

    • Family

    • Not found

    • Gene

    • psn4

    • Sequence

    • FLSLIPHAINAVSTLVHHSG

    • Sequence Length

    • 20

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antiprotozoal

    • Target Organism

    • Trypanosoma cruzi (IC50=5.1 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01292 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01292.

Physicochemical Information

    • Formula

    • C97H153N27O26

    • Absent Amino Acids

    • CDEKMQRWY

    • Common Amino Acids

    • HLS

    • Mass

    • 2113.45

    • PI

    • 7.02

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +3

    • Boman Index

    • 6.83

    • Hydrophobicity

    • 0.85

    • Aliphatic Index

    • 136.5

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 6

DRAMP01292

DRAMP01292 chydropathy plot

Comments Information

    • Function

    • Has antiprotozoal activity against Trypanosoma cruzi.

    • Tissue specificity

    • Expressed by the skin glands.

    • PTM

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • Phylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from the Phyllomedusa genus.

    • Reference

    • Peptides. 2005 Apr;26(4):565-573.

    • Author

    • Leite JR, Silva LP, Rodrigues MI, Prates MV, Brand GD, Lacava BM, Azevedo RB, Bocca AL, Albuquerque S, Bloch C Jr.