General Information

    • DRAMP ID

    • DRAMP01295

    • Peptide Name

    • Distinctin-like peptide (Frogs, amphibians, animals)

    • Source

    • Phyllomedusa azurea (Orange-legged monkey frog) (Phyllomedusa hypochondrialis azurea)

    • Family

    • Belongs to the frog skin active peptide family

    • Gene

    • ppdis-H1

    • Sequence

    • NLVSALIEGRKYLKNVLKKLNRLKEKNKAKNSKENN

    • Sequence Length

    • 36

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01295 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01295.

Physicochemical Information

    • Formula

    • C184H324N58O53

    • Absent Amino Acids

    • CDFHMPQTW

    • Common Amino Acids

    • K

    • Mass

    • 4196.95

    • PI

    • 10.36

    • Basic Residues

    • 11

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +8

    • Boman Index

    • -106.56

    • Hydrophobicity

    • -1.197

    • Aliphatic Index

    • 97.5

    • Half Life

      • Mammalian:1.4 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 42.57

    • Polar Residues

    • 11

DRAMP01295

DRAMP01295 chydropathy plot

Comments Information

    • Function

    • Has antimicrobial activity (By similarity).

    • Tissue specificity

    • Expressed by the skin glands.

Literature Information

  • ·Literature 1

    • Title

    • A genomic/proteomic approach to isolating and identifying bioactive peptides from the skin secretions of Phyllomedusa hypochondrialis azurea.

    • Reference

    • Thesis (2006), University of Ulster Coleraine, United Kingdom

    • Author

    • Thompson AH.