• DRAMP ID

    • DRAMP01299
    • Peptide Name

    • Hyposin-HA4 (Hyposin-4; Frogs, amphibians, animals)
    • Source

    • Phyllomedusa azurea (Orange-legged monkey frog) (Phyllomedusa hypochondrialis azurea)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • FRPALIVRTKGTRL
    • Sequence Length

    • 14
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial
    • Target Organism

    • No MICs found in DRAMP database
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01299 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01299.
    • Formula

    • C74H130N24O17
    • Absent Amino Acids

    • CDEHMNQSWY
    • Common Amino Acids

    • R
    • Mass

    • 1628
    • PI

    • 12.3
    • Basic Residues

    • 4
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 6
    • Net Charge

    • +4
    • Boman Index

    • -30.92
    • Hydrophobicity

    • 0.007
    • Aliphatic Index

    • 111.43
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 3

DRAMP01299

    • Function

    • Has antimicrobial activity.
    • PTM

    • C-terminal amidation.
  • ·Literature 1
    • Title

    • Amphibian skin secretomics: application of parallel quadrupole time-of-flight mass spectrometry and peptide precursor cDNA cloning to rapidly characterize the skin secretory peptidome of Phyllomedusa hypochondrialis azurea: discovery of a novel peptide family, the hyposins.
    • Reference

    • J Proteome Res. 2007 Sep;6(9):3604-3613.
    • Author

    • Thompson AH, Bjourson AJ, Orr DF, Shaw C, McClean S.