• DRAMP ID

    • DRAMP01305
    • Peptide Name

    • Phylloseptin-7 (PS-7; Frogs, amphibians, animals)
    • Source

    • Phyllomedusa hypochondrialis (Orange-legged leaf frog)
    • Family

    • Not found
    • Gene

    • psn7
    • Sequence

    • FLSLIPHAINAVSAIAKHFG
    • Sequence Length

    • 20
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.16963159]Gram-negative bacteria: Escherichia coli (MIC=6 µM), Pseudomonas aeruginosa (MIC=6 µM);
      • Gram-positive bacterium: Staphylococcus aureus (MIC=6 µM)
    • Hemolytic Activity

      • [Ref:16963159]Non-hemolytic activity at 6 μM against human erythrocytes
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Other Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • PDB ID

    • None
    • DRAMP01305 helical wheel diagram
    • Formula

    • C100H156N26O24
    • Absent Amino Acids

    • CDEMQRTWY
    • Common Amino Acids

    • A
    • Mass

    • 2106.5
    • PI

    • 8.76
    • Basic Residues

    • 3
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 12
    • Net Charge

    • +3
    • Boman Index

    • 14.47
    • Hydrophobicity

    • 1.035
    • Aliphatic Index

    • 132
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 4

DRAMP01305

DRAMP01305 chydropathy plot
    • Function

    • Has antibacterial activity against the Gram-negative bacteria E. coli and P. aeruginosa, and the Gram-positive bacteria
    • Tissue specificity

    • Expressed by the skin glands.
    • PTM

    • C-terminal amidation.
  • ·Literature 1
    • Title

    • Isolation and biochemical characterization of peptides presenting antimicrobial activity from the skin of Phyllomedusa hypochondrialis.
    • Reference

    • Peptides. 2006 Dec;27(12):3092-3999.
    • Author

    • Conceição K, Konno K, Richardson M, Antoniazzi MM, Jared C, Daffre S, Camargo AC, Pimenta DC.
  • ·Literature 2
    • Title

    • Elements of the granular gland peptidome and transcriptome persist in air-dried skin of the South American orange-legged leaf frog, Phyllomedusa hypocondrialis.
    • Reference

    • Peptides. 2006 Sep;27(9):2129-2136.
    • Author

    • Chen T, Zhou M, Gagliardo R, Walker B, Shaw C.