General Information

    • DRAMP ID

    • DRAMP01307

    • Peptide Name

    • Phylloseptin-8 (PS-8; Frogs, amphibians, animals)

    • Source

    • Phyllomedusa azurea (Orange-legged monkey frog) (Phyllomedusa hypochondrialis azurea)

    • Family

    • Not found

    • Gene

    • psn-8

    • Sequence

    • FLSLIPTAINAVSALAKHF

    • Sequence Length

    • 19

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01307 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01307.

Physicochemical Information

    • Formula

    • C96H153N23O24

    • Absent Amino Acids

    • CDEGMQRWY

    • Common Amino Acids

    • A

    • Mass

    • 2013.41

    • PI

    • 8.76

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +2

    • Boman Index

    • 15.62

    • Hydrophobicity

    • 1.205

    • Aliphatic Index

    • 138.95

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP01307

DRAMP01307 chydropathy plot

Comments Information

    • Function

    • Has antimicrobial activity.

    • Tissue specificity

    • Expressed by the skin glands.

    • PTM

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • A combined mass spectrometric and cDNA sequencing approach to the isolation and characterization of novel antimicrobial peptides from the skin secretions of Phyllomedusa hypochondrialis azurea.

    • Reference

    • Peptides. 2007 Jul;28(7):1331-1343.

    • Author

    • Thompson AH, Bjourson AJ, Orr DF, Shaw C, McClean S.