General Information

    • DRAMP ID

    • DRAMP01312

    • Peptide Name

    • Phylloseptin-11 (PS-11; Frogs, amphibians, animals)

    • Source

    • Phyllomedusa hypochondrialis (Orange-legged leaf frog)

    • Family

    • Not found

    • Gene

    • psn-11

    • Sequence

    • FLSLLPSLVSGAVSLVKIL

    • Sequence Length

    • 19

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01312 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01312.

Physicochemical Information

    • Formula

    • C94H162N20O24

    • Absent Amino Acids

    • CDEHMNQRTWY

    • Common Amino Acids

    • L

    • Mass

    • 1956.44

    • PI

    • 8.75

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +1

    • Boman Index

    • 33.14

    • Hydrophobicity

    • 1.863

    • Aliphatic Index

    • 194.74

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP01312

DRAMP01312 chydropathy plot

Comments Information

    • Function

    • Has antimicrobial activity.

    • Tissue specificity

    • Expressed by the skin glands.

    • PTM

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • Elements of the granular gland peptidome and transcriptome persist in air-dried skin of the South American orange-legged leaf frog, Phyllomedusa hypocondrialis.

    • Reference

    • Peptides. 2006 Sep;27(9):2129-2136.

    • Author

    • Chen T, Zhou M, Gagliardo R, Walker B, Shaw C.