General Information
-
DRAMP ID
- DRAMP01314
-
Peptide Name
- Phylloseptin 12 (PS-12; Frogs, amphibians, animals)
-
Source
- Phyllomedusa azurea (Orange-legged monkey frog) (Phyllomedusa hypochondrialis azurea)
-
Family
- Not found
-
Gene
- psn-12
-
Sequence
- FLSLLPSIVSGAVSLAKKLG
-
Sequence Length
- 20
-
UniProt Entry
- Q17UY9
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+
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Target Organism
-
- Gram-positive bacterium: Micrococcus luteus ATCC 49732 (MIC=1.3 µM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- Free
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01314.
Physicochemical Information
-
Formula
- C94H162N22O25
Absent Amino Acids
- CDEHMNQRTWY
Common Amino Acids
- L
Mass
- 2000.45
PI
- 10
Basic Residues
- 2
Acidic Residues
- 0
Hydrophobic Residues
- 11
Net Charge
- +2
-
Boman Index
- 21.38
Hydrophobicity
- 1.245
Aliphatic Index
- 156
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 6
DRAMP01314
Comments Information
Function
- Has antibacterial activity against the Gram-positive bacterium M. luteus. Does not inhibit the growth of the fungus C. albicans.
Tissue specificity
- Expressed by the skin glands.
PTM
- C-terminal amidation.
Literature Information
- ·Literature 1
-
Title
- A combined mass spectrometric and cDNA sequencing approach to the isolation and characterization of novel antimicrobial peptides from the skin secretions of Phyllomedusa hypochondrialis azurea.
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Pubmed ID
- 17553595
-
Reference
- Peptides. 2007 Jul;28(7):1331-1343.
-
Author
- Thompson AH, Bjourson AJ, Orr DF, Shaw C, McClean S.