• DRAMP ID

    • DRAMP01314
    • Peptide Name

    • Phylloseptin 12 (PS-12; Frogs, amphibians, animals)
    • Source

    • Phyllomedusa azurea (Orange-legged monkey frog) (Phyllomedusa hypochondrialis azurea)
    • Family

    • Unknown
    • Gene

    • psn-12
    • Sequence

    • FLSLLPSIVSGAVSLAKKLG
    • Sequence Length

    • 20
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Anti-Gram+, Antimicrobial
    • Target Organism

      • Gram-positive bacterium: Micrococcus luteus ATCC 49732 (MIC=1.3 µM).
    • Hemolytic activity

    • Unknown
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • DRAMP01314 helical wheel diagram
    • Formula

    • C94H162N22O25
    • Absent Amino Acids

    • CDEHMNQRTWY
    • Common Amino Acids

    • L
    • Mass

    • 2339.54
    • PI

    • 10.81
    • Basic Residues

    • 2
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 11
    • Boman Index

    • 21.38
    • Hydrophobicity

    • 124.5
    • Aliphatic Index

    • 156
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 6

DRAMP01314

DRAMP01314 chydropathy plot
    • Function

    • Has antibacterial activity against the Gram-positive bacterium M. luteus. Does not inhibit the growth of the fungus C. albicans.
    • Tissue specificity

    • Expressed by the skin glands.
    • PTM

    • C-terminal amidation.
  • Literature 1
    • Reference

    • Peptides. 2007 Jul;28(7):1331-1343.
    • Author

    • Thompson AH, Bjourson AJ, Orr DF, Shaw C, McClean S.
    • Title

    • A combined mass spectrometric and cDNA sequencing approach to the isolation and characterization of novel antimicrobial peptides from the skin secretions of Phyllomedusa hypochondrialis azurea.