General Information

    • DRAMP ID

    • DRAMP01318

    • Peptide Name

    • Antimicrobial peptide 1 (Frogs, amphibians, animals)

    • Source

    • Phyllomedusa hypochondrialis (Orange-legged leaf frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • LRPAVIVRTKAL

    • Sequence Length

    • 12

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacterium: Micrococcus luteus.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01318 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01318.

Physicochemical Information

    • Formula

    • C61H113N19O14

    • Absent Amino Acids

    • CDEFGHMNQSWY

    • Common Amino Acids

    • ALRV

    • Mass

    • 1336.69

    • PI

    • 12.01

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +3

    • Boman Index

    • -11.5

    • Hydrophobicity

    • 0.742

    • Aliphatic Index

    • 162.5

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 1

DRAMP01318

Comments Information

    • Function

    • Has antimicrobial activity against the Gram-positive bacterium M. luteus.

    • Tissue specificity

    • Expressed by the venom gland.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial peptides derived from the venom of the South American tree frog, Phyllomedusa hypochondrialis.

    • Reference

    • Submitted (APR-2005) to UniProtKB.

    • Author

    • Thompson A.H.