• • DRAMP ID

  • DRAMP01320

• • Peptide Name

  • Ranacyclin-B-AL1 (Frogs, amphibians, animals)

• • Source

  • Amolops loloensis (Ranidae frogs)

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • AAFRGCWTKNYSPKPCL

• • Sequence Length

  • 17

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Not found

• • SMILES

  • CC(C)C[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CO)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)O

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+

• • Target Organism

  • • Gram-positive bacteria:

      Target Organism	Activity
      Staphylococcus aureus	MIC=51 µM
      Bacillus subtilis	MIC=26 µM

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Cyclic

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

  • Disulfide bond between Cys6 and Cys16.

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • PDB ID

• Predicted Structure

• There is no predicted structure for DRAMP01320.

DRAMP01320

• • Function

  • Has antibacterial activity.

• ·Literature 1

• • Title

  • Bi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensive molecules in Ranidae amphibian skins.

• • Pubmed ID

  • 21927839

• • Reference

  • Amino Acids. 2012 Jul;43(1):309-316.

• • Author

  • Yan X, Liu H, Yang X, Che Q, Liu R, Yang H, Liu X, You D, Wang A, Li J, Lai R.