General Information

    • DRAMP ID

    • DRAMP01320

    • Peptide Name

    • Ranacyclin-B-AL1 (Frogs, amphibians, animals)

    • Source

    • Amolops loloensis (Ranidae frogs)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • AAFRGCWTKNYSPKPCL

    • Sequence Length

    • 17

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus (MIC=51 µM), Bacillus subtilis (MIC=26 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys6 and Cys16.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01320 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01320.

Physicochemical Information

    • Formula

    • C88H132N24O22S2

    • Absent Amino Acids

    • DEHIMQV

    • Common Amino Acids

    • ACKP

    • Mass

    • 1942.28

    • PI

    • 9.39

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +3

    • Boman Index

    • -21.42

    • Hydrophobicity

    • -0.465

    • Aliphatic Index

    • 34.71

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 7115

    • Absorbance 280nm

    • 444.69

    • Polar Residues

    • 7

DRAMP01320

Comments Information

    • Function

    • Has antibacterial activity.

Literature Information

  • ·Literature 1

    • Title

    • Bi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensive molecules in Ranidae amphibian skins.

    • Reference

    • Amino Acids. 2012 Jul;43(1):309-316.

    • Author

    • Yan X, Liu H, Yang X, Che Q, Liu R, Yang H, Liu X, You D, Wang A, Li J, Lai R.