General Information

    • DRAMP ID

    • DRAMP01338

    • Peptide Name

    • Amolopin-1a (Frogs, amphibians, animals)

    • Source

    • Amolops loloensis (Rufous-spotted torrent frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FLPMLAGLAANFLPKLFCKITKKC

    • Sequence Length

    • 24

    • Protein Existence

    • Homology

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus, Bacillus dysenteriae;
      • Gram-negative bacterium: Escherichia coli.
      • Yeast: Candida albicans.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01338 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01338.

Physicochemical Information

    • Formula

    • C127H207N29O27S3

    • Absent Amino Acids

    • DEHQRSVWY

    • Common Amino Acids

    • L

    • Mass

    • 2668.4

    • PI

    • 9.7

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +4

    • Boman Index

    • 18.33

    • Hydrophobicity

    • 0.867

    • Aliphatic Index

    • 110

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 5.43

    • Polar Residues

    • 5

DRAMP01338

DRAMP01338 chydropathy plot

Comments Information

    • Function

    • Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.

Literature Information

  • ·Literature 1

    • Title

    • Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis.

    • Reference

    • Peptides. 2006 Dec;27(12):3085-3091.

    • Author

    • Lu Y, Li J, Yu H, Xu X, Liang J, Tian Y, Ma D, Lin G, Huang G, Lai R.