• DRAMP ID

    • DRAMP01353
    • Peptide Name

    • Tigerinin-4 (Frogs, amphibians, animals)
    • Source

    • Rana tigerina (Indian bull frog)
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • RVCYAIPLPIC
    • Sequence Length

    • 11
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-, Antimicrobial
    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus ATCC 8530 (MIC=50 µg/ml);
      • Gram-negative bacteria: Escherichia coli (MIC=60 µg/ml), Pseudomonas putida NCIM 2102 (MIC=60 µg/ml).
      • Fungi: Saccharomyces cerevisiae ATCC 8530 (MIC=100 µg/ml).
    • Hemolytic activity

    • Unknown
    • Binding Target

    • Cell membrane
    • Structure

    • Beta strand-turn
    • Structure Description

    • Unknown
    • DRAMP01353 helical wheel diagram
    • Formula

    • C57H94N14O13S2
    • Absent Amino Acids

    • DEFGHKMNQSTW
    • Common Amino Acids

    • CIP
    • Mass

    • 1426.14
    • PI

    • 8.22
    • Basic Residues

    • 1
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 5
    • Boman Index

    • 8.11
    • Hydrophobicity

    • 134.55
    • Aliphatic Index

    • 141.82
    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 1615
    • Absorbance 280nm

    • 161.5
    • Polar Residues

    • 3

DRAMP01353

    • Function

    • Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.
  • Literature 1
    • Reference

    • J Biol Chem. 2001 Jan 26;276(4):2701-2707.
    • Author

    • Sai KP, Jagannadham MV, Vairamani M, Raju NP, Devi AS, Nagaraj R, Sitaram N.
    • Title

    • Tigerinins: novel antimicrobial peptides from the Indian frog Rana tigerina.