• DRAMP ID

    • DRAMP01362
    • Peptide Name

    • Frenatin-3 (Frogs, amphibians, animals)
    • Source

    • Litoria infrafrenata (Giant tree frog) (White-lipped tree frog)
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • GLMSVLGHAVGNVLGGLFKS
    • Sequence Length

    • 20
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Anti-Gram+, Anti-Gram-, Antimicrobial
    • Target Organism

      • Gram-negative bacterium: Escherichia coli (MIC=50 µg/ml);
      • Gram-positive bacteria: Leuconostoc mesenteroides (MIC=25 µg/ml), Bacillus cereus (MIC=12.5 µg/ml), Micrococcus luteus (MIC=1.5 µg/ml), Pastewella haemolytica (MIC=0.8 µg/ml), Streptococcus uberis (MIC=50 µg/ml).
    • Hemolytic activity

    • Unknown
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • DRAMP01362 helical wheel diagram
    • Formula

    • C88H146N24O24S
    • Absent Amino Acids

    • CDEIPQRTWY
    • Common Amino Acids

    • G
    • Mass

    • 2295.43
    • PI

    • 9.7
    • Basic Residues

    • 2
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 9
    • Boman Index

    • 19.99
    • Hydrophobicity

    • 100.5
    • Aliphatic Index

    • 126.5
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 8

DRAMP01362

DRAMP01362 chydropathy plot
    • Function

    • Wide spectrum antimicrobial peptide. Considered to interact with the outer lipid layer of the bacterial cell, penetrate the bacterial membrane, form ion channels, and ultimately kill the cell.
    • Tissue specificity

    • Expressed by the skin parotoid and/or rostral glands.
  • Literature 1
    • Reference

    • J Pept Sci. 1996 Mar-Apr;2(2):117-124.
    • Author

    • Raftery MJ, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ.
    • Title

    • The structures of the frenatin peptides from the skin secretion of the giant tree frog Litoria infrafrenata.