General Information

    • DRAMP ID

    • DRAMP01363

    • Peptide Name

    • Frenatin-4 (Frogs, amphibians, animals)

    • Source

    • Litoria infrafrenata (Giant tree frog) (White-lipped tree frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GFLDKLKKGASDFANALVNSIKGT

    • Sequence Length

    • 24

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • Wide spectrum antimicrobial peptide.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01363 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01363.

Physicochemical Information

    • Formula

    • C112H184N30O34

    • Absent Amino Acids

    • CEHMPQRWY

    • Common Amino Acids

    • K

    • Mass

    • 2494.87

    • PI

    • 9.53

    • Basic Residues

    • 4

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +2

    • Boman Index

    • -24.36

    • Hydrophobicity

    • -0.083

    • Aliphatic Index

    • 89.58

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 8

DRAMP01363

DRAMP01363 chydropathy plot

Comments Information

    • Function

    • Wide spectrum antimicrobial peptide. Considered to interact with the outer lipid layer of the bacterial cell, penetrate the bacterial membrane, form ion channels, and ultimately kill the cell.

    • Tissue specificity

    • Expressed by the skin parotoid and/or rostral glands.

Literature Information

  • ·Literature 1

    • Title

    • The structures of the frenatin peptides from the skin secretion of the giant tree frog Litoria infrafrenata.

    • Reference

    • J Pept Sci. 1996 Mar-Apr;2(2):117-124.

    • Author

    • Raftery MJ, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ.