General Information

    • DRAMP ID

    • DRAMP01367

    • Peptide Name

    • Maculatin-1.4 (frog, amphibia, animals)

    • Source

    • Litoria eucnemis (Australian anurans)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLLGLLGSVVSHVLPAITQHL

    • Sequence Length

    • 21

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Bacillus cereus (MIC=100 µg/ml), Bacillus cereus (MIC=6 µg/ml), Listeria innocua (MIC=100 µg/ml), Micrococcus luteus (MIC=50 µg/ml), Staphylococcus aureus (MIC=50 µg/ml), Staphylococcus epidermidis (MIC=50 µg/ml), Streptococcus uberis (MIC=50 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01367 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01367.

Physicochemical Information

    • Formula

    • C98H166N26O26

    • Absent Amino Acids

    • CDEFKMNRWY

    • Common Amino Acids

    • L

    • Mass

    • 2124.55

    • PI

    • 6.92

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +2

    • Boman Index

    • 26.96

    • Hydrophobicity

    • 1.271

    • Aliphatic Index

    • 176.19

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 6

DRAMP01367

DRAMP01367 chydropathy plot

Comments Information

    • Function

    • Shows antibacterial activity against the Gram-positive bacteria.

    • PTM

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.

    • Reference

    • Peptides. 2004 Jun; 25: 1035-1054.

    • Author

    • Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.