• DRAMP ID

    • DRAMP01372
    • Peptide Name

    • Odorranain-B1 (Frogs, amphibians, animals)
    • Source

    • Odorrana hainanensis (Odor frog) (Rana hainanensis)
    • Family

    • Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
    • Gene

    • Unknown
    • Sequence

    • AALKGCWTKSIPPKPCFGKR
    • Sequence Length

    • 20
    • Evidence code

    • Homology
    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=3.21 μg/ml);
      • Gram-positive bacteria: Staphylococcus aureus (MIC=5.83 μg/ml), Bacillus subtilis (MIC=1.85 μg/ml).
      • Yeast: Candida albicans (MIC=2.4 μg/ml).
    • Hemolytic activity

      • [Ref:17272268]Non-hemolytic activity against rabbit red blood cells
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Odorranain-B1 adopts 5.9 %
    • DRAMP01372 helical wheel diagram
    • Formula

    • C100H162N28O23S2
    • Absent Amino Acids

    • DEHMNQVY
    • Common Amino Acids

    • K
    • Mass

    • 2527.76
    • PI

    • 10.8
    • Basic Residues

    • 5
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 6
    • Boman Index

    • -19.88
    • Hydrophobicity

    • -42
    • Aliphatic Index

    • 49
    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5625
    • Absorbance 280nm

    • 296.05
    • Polar Residues

    • 6

DRAMP01372

DRAMP01372 chydropathy plot
    • Function

    • Odorranain-B1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. Has no hemolytic activity against red cell.
    • Tissue specificity

    • Expressed by the skin glands.
  • Literature 1
    • Reference

    • Mol Cell Proteomics. 2007 May;6(5):882-894.
    • Author

    • Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J.
    • Title

    • Anti-infection peptidomics of amphibian skin.