General Information
-
DRAMP ID
- DRAMP01374
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Peptide Name
- Odorranain-D1 (OdD1; Frogs, amphibians, animals)
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Source
- Odorrana grahami (Yunnanfu frog) (Rana grahami)
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Family
- Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
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Gene
- Not found
-
Sequence
- GFLDTFKNLALNAAKSAGVSVLNSLSCKLFKTC
-
Sequence Length
- 33
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Swiss_Prot Entry
- A6MBK7
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Evidence code
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-
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Target Organism
-
- [Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=16.32 μg/ml);
- Gram-positive bacteria: Staphylococcus aureus (MIC=8.16 μg/ml), Bacillus subtilis (MIC=8.16 μg/ml).
- Yeast: Candida albicans (MIC=4.08 μg/ml).
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Hemolytic Activity
-
- [Ref:17272268]Non-hemolytic activity against rabbit red blood cells
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Other Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
-
Structure Description
- Not found
-
PDB ID
- None
-
-
Physicochemical Information
-
Formula
- C155H254N40O45S2
Absent Amino Acids
- EHIMPQRWY
Common Amino Acids
- L
Mass
- 4033.06
PI
- 9.6
Basic Residues
- 4
Acidic Residues
- 1
Hydrophobic Residues
- 15
-
Boman Index
- -11.36
Hydrophobicity
- 0.509
Aliphatic Index
- 100.61
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 3.91
Polar Residues
- 13
DRAMP01374

Comments Information
Function
- Odorranain-D1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. Has no hemolytic activity against red cell.
Literature Information
- ·Literature 1
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Title
- Anti-infection peptidomics of amphibian skin.
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Pubmed ID
- 17272268
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Reference
- Mol Cell Proteomics. 2007 May;6(5):882-894.
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Author
- Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J.