• DRAMP ID

    • DRAMP01374
    • Peptide Name

    • Odorranain-D1 (OdD1; Frogs, amphibians, animals)
    • Source

    • Odorrana grahami (Yunnanfu frog) (Rana grahami)
    • Family

    • Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
    • Gene

    • Not found
    • Sequence

    • GFLDTFKNLALNAAKSAGVSVLNSLSCKLFKTC
    • Sequence Length

    • 33
    • Protein Existence

    • Transcript level
    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=16.32 μg/ml);
      • Gram-positive bacteria: Staphylococcus aureus (MIC=8.16 μg/ml), Bacillus subtilis (MIC=8.16 μg/ml).
      • Yeast: Candida albicans (MIC=4.08 μg/ml).
    • Hemolytic Activity

      • [Ref:17272268]Non-hemolytic activity against rabbit red blood cells
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Cyclization(Cys27 and Cys33)
    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bridge between Cys27 and Cys33.
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01374 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01374.
    • Formula

    • C155H254N40O45S2
    • Absent Amino Acids

    • EHIMPQRWY
    • Common Amino Acids

    • L
    • Mass

    • 3462.08
    • PI

    • 9.31
    • Basic Residues

    • 4
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 15
    • Net Charge

    • +3
    • Boman Index

    • -11.36
    • Hydrophobicity

    • 0.509
    • Aliphatic Index

    • 100.61
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 3.91
    • Polar Residues

    • 13

DRAMP01374

DRAMP01374 chydropathy plot
    • Function

    • Odorranain-D1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. Has no hemolytic activity against red cell.
  • ·Literature 1
    • Title

    • Anti-infection peptidomics of amphibian skin.
    • Reference

    • Mol Cell Proteomics. 2007 May;6(5):882-894.
    • Author

    • Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J.