• DRAMP ID

    • DRAMP01377
    • Peptide Name

    • Odorranain-G1 (OdG1; Frogs, amphibians, animals)
    • Source

    • Odorrana grahami (Yunnanfu frog) (Rana grahami)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • FMPILSCSRFKRC
    • Sequence Length

    • 13
    • Protein Existence

    • Transcript level
    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=4.68 μg/ml);
      • Gram-positive bacteria: Staphylococcus aureus (MIC=9.37 μg/ml), Bacillus subtilis (MIC=37.5 μg/ml).
      • Yeast: Candida albicans (MIC=1.10 μg/ml).
    • Hemolytic Activity

      • [Ref:17272268] It has no hemolytic activity against rabbit red blood cells
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Cyclization (Cys7 and Cys13)
    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys7 and Cys13.
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Odorranain-G1 adopts 44.1% β-sheet structure in water solution.
    • Helical Wheel Diagram

    • DRAMP01377 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • Formula

    • C70H114N20O16S3
    • Absent Amino Acids

    • ADEGHNQTVWY
    • Common Amino Acids

    • CFRS
    • Mass

    • 1587.98
    • PI

    • 9.7
    • Basic Residues

    • 3
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 4
    • Net Charge

    • +3
    • Boman Index

    • -21.48
    • Hydrophobicity

    • 0.362
    • Aliphatic Index

    • 60
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 10.42
    • Polar Residues

    • 4

DRAMP01377

    • Function

    • Odorranain-G1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. Has no hemolytic activity against red cell.
  • ·Literature 1
    • Title

    • Anti-infection peptidomics of amphibian skin.
    • Reference

    • Mol Cell Proteomics. 2007 May;6(5):882-894.
    • Author

    • Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J.