General Information

    • DRAMP ID

    • DRAMP01378

    • Peptide Name

    • Odorranain-H1 (OdH1; Frogs, amphibians, animals)

    • Source

    • Odorrana grahami (Yunnanfu frog) (Rana grahami)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GIFGKILGVGKKVLCGLSGVC

    • Sequence Length

    • 21

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=23.60 μg/ml);
      • Gram-positive bacteria: Staphylococcus aureus (MIC=5.90 μg/ml), Bacillus subtilis (MIC=5.90 μg/ml).
      • Yeast: Candida albicans (MIC=11.80 μg/ml).

    • Hemolytic Activity

      • [Ref.17272268] RCH=21.6 ± 7.3% against rabbit red blood cells. RCH, red cell hemolysis.

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Cyclization (Cys15 and Cys21)

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys15 and Cys21.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Odorranain-H1 adopts 50.3 β-sheet structure in water solution.

    • Helical Wheel Diagram

    • DRAMP01378 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01378.

Physicochemical Information

    • Formula

    • C93H162N24O23S2

    • Absent Amino Acids

    • ADEHMNPQRTWY

    • Common Amino Acids

    • G

    • Mass

    • 2048.58

    • PI

    • 9.39

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +3

    • Boman Index

    • 27.85

    • Hydrophobicity

    • 1.233

    • Aliphatic Index

    • 134.29

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 6.25

    • Polar Residues

    • 9

DRAMP01378

DRAMP01378 chydropathy plot

Comments Information

    • Function

    • Odorranain-H1 exhibites antimicrobial activities against Gram-positive and Gram-negative bacteria and fungi. Also has hemolytic activity against rabbit red cell.

Literature Information

  • ·Literature 1

    • Title

    • Anti-infection peptidomics of amphibian skin.

    • Reference

    • Mol Cell Proteomics. 2007 May;6(5):882-894.

    • Author

    • Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J.