• DRAMP ID

    • DRAMP01380
    • Peptide Name

    • Odorranain-J1 (OdJ1; Frogs, amphibians, animals)
    • Source

    • Odorrana grahami (Yunnanfu frog) (Rana grahami)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • GLFTLIKCAYQLIAPTVACN
    • Sequence Length

    • 20
    • Protein Existence

    • Transcript level
    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=35.60 μg/ml);
      • Gram-positive bacteria: Staphylococcus aureus (MIC=17.80 μg/ml), Bacillus subtilis (MIC=35.60 μg/ml).
      • Yeast: Candida albicans (MIC=8.90 μg/ml).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Odorranain-J1 adopts 50.1% β-sheet and 13.7% turn structure in water solution.
    • Helical Wheel Diagram

    • DRAMP01380 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • Formula

    • C98H159N23O26S2
    • Absent Amino Acids

    • DEHMRSW
    • Common Amino Acids

    • AL
    • Mass

    • 2139.6
    • PI

    • 8.05
    • Basic Residues

    • 1
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 10
    • Net Charge

    • +1
    • Boman Index

    • 17.54
    • Hydrophobicity

    • 1.11
    • Aliphatic Index

    • 127
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 1615
    • Absorbance 280nm

    • 85
    • Polar Residues

    • 7

DRAMP01380

DRAMP01380 chydropathy plot
    • Function

    • Odorranain-J1 exhibites moderate antimicrobial activities against Gram-positive and Gram-negative bacteria and fungi.
  • ·Literature 1
    • Title

    • Anti-infection peptidomics of amphibian skin.
    • Reference

    • Mol Cell Proteomics. 2007 May;6(5):882-894.
    • Author

    • Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J.