• DRAMP ID

    • DRAMP01386
    • Peptide Name

    • Odorranain-P1a (OdP1a; Brevinin-1HS1; Brevinin-1-OA2; Frogs, amphibians, animals)
    • Source

    • Odorrana grahami (Yunnanfu frog) (Rana grahami)
    • Family

    • Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
    • Gene

    • Not found
    • Sequence

    • VIPFVASVAAEMMQHVYCAASKKC
    • Sequence Length

    • 24
    • Protein Existence

    • Transcript level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
    • Target Organism

      • [Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=3.50 μg/ml);
      • Gram-positive bacteria: Staphylococcus aureus (MIC=3.50 μg/ml), Bacillus subtilis (MIC=1.75 μg/ml).
      • Yeast: Candida albicans (MIC=1.75 μg/ml).
    • Hemolytic Activity

      • [Ref.17272268] RCH=11.2 ± 2.9% against rabbit red blood cells. RCH, red cell hemolysis.
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01386 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01386.
    • Formula

    • C114H183N29O31S4
    • Absent Amino Acids

    • DGLNRTW
    • Common Amino Acids

    • A
    • Mass

    • 2584.12
    • PI

    • 8.02
    • Basic Residues

    • 3
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 11
    • Net Charge

    • +2
    • Boman Index

    • 5.32
    • Hydrophobicity

    • 0.808
    • Aliphatic Index

    • 85.42
    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 1615
    • Absorbance 280nm

    • 70.22
    • Polar Residues

    • 5

DRAMP01386

DRAMP01386 chydropathy plot
    • Function

    • Odorranain-P1a exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. Also has hemolytic activity against rabbit red cell.
  • ·Literature 1
    • Title

    • Anti-infection peptidomics of amphibian skin.
    • Reference

    • Mol Cell Proteomics. 2007 May;6(5):882-894.
    • Author

    • Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J.