General Information

    • DRAMP ID

    • DRAMP01401

    • Peptide Name

    • Odorranain-F-OW1 (Frogs, amphibians, animals)

    • Source

    • Odorrana wuchuanensis (Chinese odorous frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GFMNTAKNVAKNVAVTLLDNLKCKITGGC

    • Sequence Length

    • 29

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacteria: Escherichia coli (MIC=2 µM), Pseudomonas aeruginosa (MIC=4 µM);
      • Gram-positive bacterium: Staphylococcus aureus (MIC=4 µM).
      • Yeast: Candida albicans ATCC 2002 (MIC=2 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Cyclization (Cys23 and Cys29)

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys23 and Cys29.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01401 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C130H223N37O39S3

    • Absent Amino Acids

    • EHPQRSWY

    • Common Amino Acids

    • KN

    • Mass

    • 3024.61

    • PI

    • 9.31

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +3

    • Boman Index

    • -17.25

    • Hydrophobicity

    • 0.248

    • Aliphatic Index

    • 94.14

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 4.46

    • Polar Residues

    • 12

DRAMP01401

DRAMP01401 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs.

    • Reference

    • J Proteome Res. 2012 Jan 1;11(1):306-319.

    • Author

    • Yang X, Lee WH, Zhang Y.