General Information

    • DRAMP ID

    • DRAMP01419

    • Peptide Name

    • Nigrocin-2GRc (Frogs, amphibians, animals)

    • Source

    • Rana grahami (Asian frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLLSGILGAGKNIVCGLSGLC

    • Sequence Length

    • 21

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • [Ref.16621155]Gram-negative bacterium: Escherichia coli (MIC=50 µM).

    • Hemolytic Activity

      • [Ref:16621155] LC50>500 μM against human erythrocytes

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Cyclization (Cys15 and Cys21)

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys15 and Cys21.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01419 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C84H149N23O25S2

    • Absent Amino Acids

    • DEFHMPQRTWY

    • Common Amino Acids

    • G

    • Mass

    • 1945.37

    • PI

    • 8.06

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +1

    • Boman Index

    • 29.5

    • Hydrophobicity

    • 1.314

    • Aliphatic Index

    • 148.57

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 6.25

    • Polar Residues

    • 11

DRAMP01419

DRAMP01419 chydropathy plot

Comments Information

    • Function

    • Has antibacterial against Gram-negative bacterium E. coli. Also has a weak hemolytic activity against human erythrocytes.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial peptides from diverse families isolated from the skin of the Asian frog, Rana grahami.

    • Reference

    • Peptides. 2006 Sep;27(9):2111-2117.

    • Author

    • Conlon JM, Al-Ghaferi N, Abraham B, Jiansheng H, Cosette P, Leprince J, Jouenne T, Vaudry H.