General Information

    • DRAMP ID

    • DRAMP01423

    • Peptide Name

    • Nigrosin-OG13 (Frogs, amphibians, animals)

    • Source

    • Odorrana grahami (Yunnanfu frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLLSGILGAGKHIVCGLSGLR

    • Sequence Length

    • 21

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacterium: Escherichia coli (MIC=4.68 µg/ml);
      • Gram-positive bacteria: Staphylococcus aureus (MIC=9.37 µg/ml), Bacillus subtilis (MIC=18.75 µg/ml).
      • Yeast: Candida albicans (MIC=1.10 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01423 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01423.

Physicochemical Information

    • Formula

    • C89H157N27O24S

    • Absent Amino Acids

    • DEFMNPQTWY

    • Common Amino Acids

    • G

    • Mass

    • 2021.45

    • PI

    • 9.51

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +3

    • Boman Index

    • 15.28

    • Hydrophobicity

    • 0.995

    • Aliphatic Index

    • 148.57

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 9

DRAMP01423

DRAMP01423 chydropathy plot

Comments Information

    • Function

    • Has antibacterial and antifungal activity.

Literature Information

  • ·Literature 1

    • Title

    • Anti-infection peptidomics of amphibian skin.

    • Reference

    • Mol Cell Proteomics. 2007 May;6(5):882-894.

    • Author

    • Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J.