• DRAMP ID

    • DRAMP01465
    • Peptide Name

    • Esculentin-1R (Frogs, amphibians, animals)
    • Source

    • Rana ridibunda (Laughing frog) (Marsh frog)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • Not found
    • Sequence

    • GIFSKLAGKKLKNLLISGLKSVGKEVGMDVVRTGIDIAGCKIKGEC
    • Sequence Length

    • 46
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

    • [Swiss_Prot Entry P86018]Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species
    • Hemolytic Activity

      • [Ref:18855342]Low hemolytic activity
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01465 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01465.
    • Formula

    • C211H370N58O60S3
    • Absent Amino Acids

    • HPQWY
    • Common Amino Acids

    • GK
    • Mass

    • 4775.79
    • PI

    • 9.63
    • Basic Residues

    • 9
    • Acidic Residues

    • 4
    • Hydrophobic Residues

    • 17
    • Net Charge

    • +5
    • Boman Index

    • -25.4
    • Hydrophobicity

    • 0.263
    • Aliphatic Index

    • 114.35
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 2.78
    • Polar Residues

    • 15

DRAMP01465

DRAMP01465 chydropathy plot
    • Function

    • Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity.
    • Tissue specificity

    • Expressed by the skin glands.
    • PTM

    • Contains one disulfide bond 40-46.
  • ·Literature 1
    • Title

    • De novo sequencing of peptides secreted by the skin glands of the Caucasian Green Frog Rana ridibunda.
    • Reference

    • Rapid Commun Mass Spectrom. 2008 Nov;22(22):3517-3525.
    • Author

    • Samgina TY, Artemenko KA, Gorshkov VA, Ogourtsov SV, Zubarev RA, Lebedev AT.