General Information

    • DRAMP ID

    • DRAMP01466

    • Peptide Name

    • Esculentin-2R (Frogs, amphibians, animals)

    • Source

    • Rana ridibunda (Laughing frog) (Marsh frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • GILSLVKVAKLAGKTFAKEGGKFGLEFIACKVTNQC

    • Sequence Length

    • 36

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01466 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01466.

Physicochemical Information

    • Formula

    • C172H286N44O46S2

    • Absent Amino Acids

    • DHMPRWY

    • Common Amino Acids

    • K

    • Mass

    • 3770.55

    • PI

    • 9.51

    • Basic Residues

    • 6

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 16

    • Net Charge

    • +4

    • Boman Index

    • -2.56

    • Hydrophobicity

    • 0.439

    • Aliphatic Index

    • 100.28

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 3.57

    • Polar Residues

    • 11

DRAMP01466

DRAMP01466 chydropathy plot

Comments Information

    • Function

    • Antimicrobial peptide.

    • Tissue specificity

    • Expressed by the skin glands.

    • PTM

    • Contains one disulfide bond 30-36.

Literature Information

  • ·Literature 1

    • Title

    • De novo sequencing of peptides secreted by the skin glands of the Caucasian Green Frog Rana ridibunda.

    • Reference

    • Rapid Commun Mass Spectrom. 2008 Nov;22(22):3517-3525.

    • Author

    • Samgina TY, Artemenko KA, Gorshkov VA, Ogourtsov SV, Zubarev RA, Lebedev AT.