• DRAMP ID

    • DRAMP01483
    • Peptide Name

    • Esculentin-1ISb (Frogs, amphibians, animals)
    • Source

    • Odorrana ishikawae (Japanese Endangered frog)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • Not found
    • Sequence

    • RIFSKIGGKAIKNLILKGIKNIGKEVGMDVIRTGIDVAGCKIKGEC
    • Sequence Length

    • 46
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
    • Target Organism

      • Gram-negative bacterium: Escherichia coli (MC=3.1 µM);
      • Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 µM), Staphylococcus aureus (MRSA) (MIC=12.5 µM), Bacillus subtilis (MIC=12.5 µM).
      • Yeast: Candida albicans (MIC=50 µM).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Cyclization (Cys40 and Cys46)
    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys40 and Cys46.
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01483 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01483.
    • Formula

    • C216H380N62O59S3
    • Absent Amino Acids

    • HPQWY
    • Common Amino Acids

    • I
    • Mass

    • 4885.95
    • PI

    • 9.83
    • Basic Residues

    • 10
    • Acidic Residues

    • 4
    • Hydrophobic Residues

    • 17
    • Net Charge

    • +6
    • Boman Index

    • -39.28
    • Hydrophobicity

    • 0.176
    • Aliphatic Index

    • 116.52
    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 2.78
    • Polar Residues

    • 14

DRAMP01483

DRAMP01483 chydropathy plot
    • Function

    • Shows antibacterial activity.
  • ·Literature 1
    • Title

    • Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae.
    • Reference

    • Peptides. 2011 Apr;32(4):670-676.
    • Author

    • Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M.