• DRAMP ID

    • DRAMP01492
    • Peptide Name

    • Esculentin-IIb (Frogs, amphibians, animals)
    • Source

    • Rana esculenta (European Edible frog)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • Not found
    • Sequence

    • GIFSLVKGAAKLAGKGLAKEGGKFGLELIACKIAKQC
    • Sequence Length

    • 37
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

    • [Swiss_Prot Entry P40846]Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species
    • Hemolytic Activity

      • [Ref:8163497]Not found
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01492 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01492.
    • Formula

    • C169H289N45O44S2
    • Absent Amino Acids

    • DHMNPRTWY
    • Common Amino Acids

    • GK
    • Mass

    • 3719.55
    • PI

    • 9.7
    • Basic Residues

    • 7
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 17
    • Net Charge

    • +5
    • Boman Index

    • 7.95
    • Hydrophobicity

    • 0.451
    • Aliphatic Index

    • 108.38
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 3.47
    • Polar Residues

    • 10

DRAMP01492

DRAMP01492 chydropathy plot
    • Function

    • Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species.
  • ·Literature 1
    • Title

    • Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides.
    • Reference

    • J Biol Chem. 1994 Apr 22;269(16):11956-11961.
    • Author

    • Simmaco M, Mignogna G, Barra D, Bossa F.