General Information

    • DRAMP ID

    • DRAMP01495

    • Peptide Name

    • Esculentin-1-OA3 (Frogs, amphibians, animals)

    • Source

    • Odorrana andersonii (Chinese odorous frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • GLFSKFAGKGIKDLIFKGVKHIGKEVGMDVIRVGIDVAGCKIKGVC

    • Sequence Length

    • 46

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=5.4 µg/mL);
      • Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=5.4 µg/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=2.7 µg/mL).
      • Yeast: Candida albicans ATCC 2002 (MIC=2.7 µg/mL).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Cyclization (Cys40 and Cys46)

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys40 and Cys46.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01495 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01495.

Physicochemical Information

    • Formula

    • C220H369N59O56S3

    • Absent Amino Acids

    • NPQTWY

    • Common Amino Acids

    • G

    • Mass

    • 4832.89

    • PI

    • 9.63

    • Basic Residues

    • 10

    • Acidic Residues

    • 4

    • Hydrophobic Residues

    • 19

    • Net Charge

    • +6

    • Boman Index

    • -10.82

    • Hydrophobicity

    • 0.465

    • Aliphatic Index

    • 110

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 2.78

    • Polar Residues

    • 12

DRAMP01495

DRAMP01495 chydropathy plot

Comments Information

    • Function

    • Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans.

Literature Information

  • ·Literature 1

    • Title

    • Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.

    • Reference

    • J Proteome Res. 2012 Jan 1;11(1):306-319.

    • Author

    • Yang X, Lee WH, Zhang Y.